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๐Ÿ”ฅ+ best cabbage for diabetics 09 Aug 2020 The term diabetes mellitus describes a metabolic disorder of multiple aetiology characterised by chronic hyperglycaemia with disturbances of carbohydrate, fat, ...

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Table of Contents

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# 606394

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MODY, TYPE 6


Phenotype-Gene Relationships

Location Phenotype Phenotype
MIM number
Inheritance Phenotype
mapping key
Gene/Locus Gene/Locus
MIM number
2q31.3 Maturity-onset diabetes of the young 6 606394 3 NEUROD1 601724

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A number sign (#) is used with the 1 last update 09 Aug 2020 this entry because of evidence that maturity-onset diabetes of the young type 6 (MODY6) is caused by heterozygous mutation in the NEUROD1 gene (601724) on chromosome 2q31.A number sign (#) is used with this entry because of evidence that maturity-onset diabetes of the young type 6 (MODY6) is caused by heterozygous mutation in the NEUROD1 gene (601724) on chromosome 2q31.

For a general phenotypic description and a discussion of genetic heterogeneity of MODY, see 606391.


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In a family reported by Malecki et al. (1999), members with mutations in the NEUROD1 gene met the diagnostic criteria for MODY including an autosomal pattern of inheritance, onset of diabetes before 25 years of age in 3 carriers, and a requirement for insulin treatment in 5 carriers; see 601724.0002.


Pathogenesis

In a review of the various forms of MODY, Fajans et al. (2001) suggested that the molecular basis of MODY6 is abnormal transcription/regulation of beta cell development and function. the 1 last update 09 Aug 2020


REFERENCES

  1. best cabbage for diabetics sugar level (๐Ÿ”ด mellitus nature reviews) | best cabbage for diabetics ketoneshow to best cabbage for diabetics for Fajans, S. S., Bell, G. I., Polonsky, K. S. Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. New Eng. J. Med. 345: 971-980, 2001. [PubMed: 11575290, related citations] [Full Text]

  2. Malecki, M. T., Jhala, U. S., Antonellis, A., Fields, L., Doria, A., Orban, T., Saad, M., Warram, J. H., Montminy, M., Krolewski, A. S. Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. Nature Genet. 23: 323-328, 1999. [PubMed: 10545951, related citations] [Full Text] Malecki, M. T., Jhala, U. S., Antonellis, A., Fields, L., Doria, A., Orban, T., Saad, M., Warram, J. H., Montminy, M., Krolewski, A. S. Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. Nature Genet. 23: 323-328, 1999. [PubMed: 10545951, related citations] [Full Text]


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